E Locus (Extension)

The MC1R-gen (Melanocortin 1 receptor) has been identified on the canine chromosome 5 (Schmutz et al. 2001). In this locus, 3 alleles E, e and EM are known. The original, so-called wild type allele E (non-mutated allele), the allele e created by mutation c. 914C>T (Newton et al. 2000, Schmutz et al. 2002), which causes the loss of gene function and is responsible for bright red or yellow coat colour in genotype e/e.

Example of coat colour of a dog of genotype e/e:

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The E-locus test is suitable in particular for the following breeds: Afghan, Australian cattle dog, Australian Shepherd, Beagle, Border collie, Brittany Spaniel, Cardigan Welsh Corgi, Chinese Shar-Pei, Chow Chow, Cocker Spaniel, Dachshund, Dalmatian, Doberman Pinscher, English Cocker Spaniel, English Setter, English Springer Spaniel, Field Spaniel, Flatcoated Retriever, Foxhound, French Bull Dog, German Longhaired Pointer, German Shepherd, German Wirehaired Pointer, Labrador Retriever, Lowchen, Pointer, Pomeranian, Poodle, Pudelpointer.

Fo information about melanistic mask, the allele EM, please continue here.

What is the relationship of E-locus to A and K loci? Continue and have a look at the dominance hierarchy of allele affecting the coat colour in dogs.

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Information about ordering the locus tests

The prices of the individual locus tests are stated in the price list. To each order of coat colour test for one dog, an extra fee amounting to 16.60 EUR incl. VAT will be charged for preparation of the sample and DNA-isolation.

Example: You order tests for loci E, K and A for one dog - total price = 16.70 EUR + 33.30 EUR (locus E) + 33.30 EUR (locus K) + 33.30 EUR (locus A) = 116.50 EUR

If any other genetic examination is ordered in addition to the locus test, you will get a discount.