Statistical overview of IVDD and PRA-prcd for Coton de Tulear

Statistical overview of IVDD and PRA-prcd in Coton de Tulears

-> Chondrodysplasia, chondrodystrophy and degeneration of intervertebral discs.

From August 2018 to February 2019 Genomia laboratory tested 59 dogs of Coton de Tulear breed for CDPA / CDDY (IVDD)  - the tests discovered two insertion mutations of retrogene for fibroblast growth factor  FGF4 in chromosomes 12 and 18. For more information about the disease and the tests, see the page with CDPA / CDDY IVDD examination.

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The following genotypes have been found in the tested set of samples:

  • 23 dogs CDDY/CDDY => 39 % of these dogs are at risk for IVDD development; the mutation causes shortening of limps compared to dogs with genotype N/N and dogs with genotype B/CDDY.   The offspring will have short legs and at risk for IVDD.
  • 23 dogs N/CDDY => 39 % of these dogs are at risk for IVDD; the mutation causes shortening of limbs compared to dogs with N/N-genotype. When bred to an N/N dogs, 50% will have normal size limbs (N/N) and 50% will have shorter legs and will be at risk for IVDD (N/CDDY).
  • 13 dogs N/N => 22 % will be at no risk for IVDD

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Note:  All  Coton de Tulear dogs are detected as homozygous for CDPA/CDPA – that means that the dogs normally have short legs. It is a characteristic trait of this breed and in this case Chondrodysplasia is not an unwanted condition.

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-> Progressive retinal atrophy - prcd form

From November 2018 to February 2019 Genomia performed tests of 112 dogs of Coton de Tulear breed for PRA-prcd  - it has been detected a mutation 1298G>A in PRCD-gene. For more information about the disease and the tests, see the page with PRA-prcd examination.

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In the tested set of samples, the following genotypes have been found:

  • 93 dogs with N/N genotype => 83 %
  • 19 dogs with N/P genotype  => 17 % of these dogs are carriers of PRA-prcd
  • 0 dogs with P/P genotype

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The tested set of dogs includes related and non-related dogs from European countries. It is obvious that the mutant allele is markedly spread in Coton de Tulear dogs.  To avoid birth of dogs with PRA-prcd eye disorder, it is necessary to check the parents before breeding. The optimal strategy is to have one parent tested for N/N genotype so that only puppies with N/N or N/P genotype are born.

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Plzeň, Czech Republic, 12.3.2019

Genomia Team