
Testing of cats: GM2
GM2 gangliosidosis in Japanese bobtail cat
GM2 is an autosomal recessive disorder. The disease affects cats with P/P (positive / positive) genotype only. Cats with P/N (positive /negative) genotype are clinically without any symptoms. They are genetically considered carriers of the disease (heterozygotes). In offspring of two heterozygous animals following genotype distribution can be expected: 25 % N/N (healthy non-carriers), 25 % P/P (affected), and 50 % N/P (healthy carriers). Because of high risk of producing affected offspring, mating of two N/P animals (carriers) can not be recommended.
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References:
Hasegawa, D., Yamato, O., Kobayashi, M., Fujita, M., Nakamura, S., Takahashi, K., Satoh, H., Shoda, T., Hayashi, D., Yamasaki, M., Maede, Y., Arai, T., Orima, H. : Clinical and molecular analysis of GM2 gangliosidosis in two apparent littermate kittens of the Japanese domestic cat. J Feline Med Surg 9:232-7, 2007. Pubmed reference: 17198760.