DM: Statistical overview of results in several canine breeds

Degenerative myelopathy

A statistical overview of DM results in several canine breeds

Here, you can find frequencies of occurrence of the mutation c.118G> A in the SOD1 gene that causes degenerative myelopathy in many dog breeds. In details, there are listed breeds with high occurrence of the mutation in the population. Samples originated from different countries and tested in 2013-2018 were included in statistical calculation. Related and unrelated dogs were included in testing set of samples. In breeds, that are marked with *, there are included less then 50 samples in the testing set, so distribution of the mutation in real population of these breeds may be different.

.

American hairless terrier

  • normal genotype 54%
  • carrier 39%
  • mutated homozygote = dog at risk of DM development 7%

.

Australian Shepperd

  • normal genotype 78%
  • carrier 21%
  • mutated homozygote = dog at risk of DM 1%

.

Coton de Tulear

  • normal genotype 92%
  • carrier 8%
  • mutated homozygote = dog at risk of DM development 0%

.

Czechoslovakian Wolfdog

  • normal genotype 73%
  • carrier 25%
  • mutated homozygote = dog at risk of DM 2%

.

French Bulldog*

  • normal genotype 70%
  • carrier 26%
  • mutated homozygote = dog at risk of DM development 4%

.

Dutch Shepherd

  • normal genotype 87%
  • carrier 13%
  • mutated homozygote = dog at risk of DM development 0%

.

Hovawart

  • normal genotype 44%
  • carrier 44%
  • mutated homozygote = dog at risk of DM 12%

.

Cavalier King Charles Spaniel

  • normal genotype 18%
  • carrier 46%
  • mutated homozygote = dog at risk of DM development 36%

.

German Shepherd

  • normal genotype 61%
  • carrier 34%
  • mutated homozygote = male at risk of DM development 5%

.

Parson Russel Terrier *

  • normal genotype 80%
  • carrier 20%
  • mutated homozygote = dog at risk of DM development 0%
.

Mutated homozygotes and heterozygotes have been found also among other breeds, but the numbers of tested dogs of the particular breeds are too small to be able to do statistical evaluation. Breeds in which mutated homozygotes and heterozygotes were found:

  • Pyrenean mountain dog
  • Bohemian shepherd
  • Welsh Corgi Pembroke
  • Welsh Corgi Cardigan
  • Barzoi
  • Landseer
  • Bernese Mountain Dog (beware - there are other mutations responsible for DM, also compound heterozygotes can be affected by DM)
  • Irish Soft Coated Wheaten Terrier
  • Rough and Smooth Collie
  • Kerry Blue Terrier
.

Heterozygotes were found among representatives of these breeds : Finnish Lapphund, Podle standard and miniature, Cockapoo, Rhodesian Ridgeback, Canaan Dog, White Swiss Shepherd, Mastiff, Labradoodle, Jack Russell Terrier, Miniature Australian Shepherd, Chinese Crested Dog.

.

The list of breeds with occurence od DM mutation, that is mentioned above, is not final because there are no data available for many breeds.

.

Pilsen, Czech Republic, November 19, 2018

Genomia team