Testing of dogs: Cataract

Usual turnaround time: 12 business days

1 test price: 56.00 $ without VAT

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Cataract in Wirehaired Pointing Griffon

Cataracts are a disease that affects the lens of the eye and causes it to become cloudy. Gradual deterioration of vision is evident in puppies as young as 8 weeks of age. Opaque spots form on the lens of the eye, leading to loss of vision.

The disease is caused by mutation c.2024delG in the FYCO1 gene, which plays an important role in maintaining the homeostasis of the eye.

The mode of inheritance of the mutation is autosomal recessive. This means that only individuals who inherit the mutated gene from both parents will develop the disease. Carriers of the mutated gene are clinically healthy but pass the mutation on to their offspring. In the case of a mating between two heterozygous individuals, theoretically 25% of the offspring will be completely healthy, 50% of the offspring will be carriers and 25% of the offspring will inherit the mutated gene from both parents and will therefore be affected by the disease.

The genetic test can clearly reveal the genotype of the animal and is a useful tool for breeders to prevent unintentional breeding of affected puppies.

References:

Rudd Garces, G., Christen, M., Loechel, R., Jagannathan, V., Leeb, T. : FYCO1 frameshift deletion in Wirehaired Pointing Griffon dogs with juvenile cataract. Genes (Basel) 13:334, 2022. Pubmed reference: 35205377

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