Testing of cats: Locus B feline

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Usual turnaround time: 7 business days
1 test price: 42.00 $ without VAT
Price for 5+ tests: 38.00 $ without VAT

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Locus B (Brown - chocolate, cinnamon)

The locus B is responsible for the brown coat colour, namely the variants in TYRP1 gene (tyrosinase-related protein 1), which is associated with this locus. In cats, a series of alleles B˃b˃bl has been described.

The allele B is the original (wild type) allele and determines the dark colour; the B-allele is dominant in this series.

In connection with b-allele (chocolate), the variants c.8C˃G (p.A3G) and c.1262+5G˃A have been described.

The variant c.298C˃T (p.R100X) has been described in connection with bl -allele (cinnamon) (Lyons et al. 2005).

The brown and cinnamon colour is autosomal recessively inherited colour, i.e. the phenotype comes to expression only in cats which inherited these b-alleles from their parents. A cat with genotype b/b has a chocolate-brown colour and a cat of genotype bl/bl has a light brown (cinnamon) colour.

Example of cinnamon coat color:

cinnamon

.

Example of chocolate coat color:

chocolate

.

Genotypes:

  • a cat with B/B genotype transmits neither b-allele (for chocolate colour) nor bl -allele (for cinnamon colour)
  • a cat with B/b genotype is a carrier of b-allele b (chocolate)
  • a cat with B/bl -genotype is a carrier of bl -allele (cinnamon )
  • a cat with b/b-genotype with chocolate-brown colour (homozygous for chocolate allele - this individual always passes this allele on to its offsprings)
  • a cat with b/bl -genotype with chocolate-brown colour is a carrier of bl-allele (cinnamon)
  • a cat with bl /bl -genotype with cinnamon colour (homozygous for cinnamon allele - this individual always passes this allele on to its offsprings)

.

References:

Lyons, L. A., I. T. Foe, H. C. Rah and R. A. Grahn, 2005 Chocolate coated cats: TYRP1 mutations for brown color in domestic cats. Mamm. Genome 16: 356-366.

Schmidt-Küntzel, A., E. Eizirik, S. J. O'Brien and M. Menotti-Raymond, 2005 Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of the albino and brown loci. J. Hered. 96: 289-301.

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Usual turnaround time: 7 business days
1 test price: 42.00 $ without VAT
Price for 5+ tests: 38.00 $ without VAT