Testing of cats: Locus B feline

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For operational reasons, we have temporarily interrupted testing for appearance traits in cats. Tests are going to be performed only in predetermined action weeks during which you must deliver the samples to the laboratory. Online placement of test orders and sample kits orders will be launched one week ahead of this action week. Thank you for your understanding. Next feline week is: 17-23.1.2022

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Locus B (Brown - chocolate, cinnamon)

The locus B is responsible for the brown coat colour, namely the variants in TYRP1 gene (tyrosinase-related protein 1), which is associated with this locus. In cats, a series of alleles B˃b˃bl has been described.

The allele B is the original (wild type) allele and determines the dark colour; the B-allele is dominant in this series.

In connection with b-allele (chocolate), the variants c.8C˃G (p.A3G) and c.1262+5G˃A have been described.

The variant c.298C˃T (p.R100X) has been described in connection with bl -allele (cinnamon) (Lyons et al. 2005).

The brown and cinnamon colour is autosomal recessively inherited colour, i.e. the phenotype comes to expression only in cats which inherited these b-alleles from their parents. A cat with genotype b/b has a chocolate-brown colour and a cat of genotype bl/bl has a light brown (cinnamon) colour.

Example of cinnamon coat color:

cinnamon

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Example of chocolate coat color:

chocolate

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Genotypes:

  • a cat with B/B genotype transmits neither b-allele (for chocolate colour) nor bl -allele (for cinnamon colour)
  • a cat with B/b genotype is a carrier of b-allele b (chocolate)
  • a cat with B/bl -genotype is a carrier of bl -allele (cinnamon )
  • a cat with b/b-genotype with chocolate-brown colour (homozygous for chocolate allele - this individual always passes this allele on to its offsprings)
  • a cat with b/bl -genotype with chocolate-brown colour is a carrier of bl-allele (cinnamon)
  • a cat with bl /bl -genotype with cinnamon colour (homozygous for cinnamon allele - this individual always passes this allele on to its offsprings)

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References:

Lyons, L. A., I. T. Foe, H. C. Rah and R. A. Grahn, 2005 Chocolate coated cats: TYRP1 mutations for brown color in domestic cats. Mamm. Genome 16: 356-366.

Schmidt-Küntzel, A., E. Eizirik, S. J. O'Brien and M. Menotti-Raymond, 2005 Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of the albino and brown loci. J. Hered. 96: 289-301.

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online ordering not possible.
1 test price: 42.00 $ without VAT