Testing of dogs: Locus EG

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Usual turnaround time: 7 business days
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Locus EG

The allele EG is responsible for the grizzle coloration in Saluki breed and domino colour in Afghan Hounds. A mutation in the MC1R-gene occurs (c.233G>T) in both breeds. The phenotype connected with this mutation is light hair on the face and eyebrows.

The mutant EG-allele is dominant over E and e alleles but recessive to the EM allele. The expression of EG allele is influenced particularly by A-locus. The grizzle and domino colours occur only in dogs possessing two at alleles. If a dog carries one or two ay alleles, the grizzle or domino colours will remain hidden. The expression of this colour in puppies within the litter will depend mainly on the fact whether one parent dog has one or two EG alleles and its partner the at allele in its genotype.  Further, a complicating factor is the presence of EM that cancels the effect of the EG allele.

Locus E hierarchy is as follows: EM> EG> E> EH> e. To determine the final locus E genotype, it is necessary to test all locus E alleles. This test only detects the presence or absence of EG allele.

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Rules of inheritance of grizzle and domino coloration:

  • Grizzle or domino colour can only occur in dogs that have  at least one EG allele and two at alleles; an exception is situation when the EG allele is not expressed due its combination with the EM allele which suppresses the effect of  EG allele
  • If a dog carries at least one EG allele and only one at allele, the grizzle or domino colour will not express, but can be passed on to offsprings and expressed in a later generation
  • If a dog carries at least one EG allele and two ayalleles, the grizzle or domino coloration will not be expressed and will be only passed on to next generations.

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1. Possible genotypes - Saluki

Example of Saluki in grizzle color:

saluki grizzle

saluki

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Genotype

Colour

Carrier of colour

EG/EG

at/ at

grizzle

eumelanin-and-tan

EG/E

at/ at

grizzle

eumelanin-and-tan

EG/e

at/ at

grizzle

red, eumelanin-and-tan

EM/EG

at/ at

eumelanin-and-tan, with mask

grizzle, eumelanin-and-tan, with mask

EM/EG

ay/ ay

red or cream with mask

grizzle

EG/EG

ay/ ay

red or cream

grizzle

EG/E

ay/ ay

red or cream

grizzle

EG/e

ay/ ay

red or cream

grizzle,red

EM/EG

ay/ at

red or cream, with mask

grizzle, eumelanin-and-tan

EG/EG

ay/ at

red or cream

grizzle, eumelanin-and-tan

EG/E

ay/ at

red or cream

grizzle, eumelanin-and-tan

EG/e

ay/ at

red or cream

red, grizzle, eumelanin-and-tan

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2. Possible genotypes – Afghan hound

Example of Afghan hound in domino color:

Afghansky-chrt-domino

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Genotype

Colour

Carrier of colour

EG/EG

at/at

domino

black and tan, with mask

EG/E

at/at

domino

black and tan, with mask

EG/e

at/at

domino

red, black and tan, with mask

EM/EG

at/at

black and tan, with mask

domino, black and tan, with mask

EM/EG

ay/ay

red or cream

domino

EG/EG

ay/ay

red or cream

domino

EG/E

ay/ay

red or cream

domino

EG/e

ay/ay

red or cream

domino, red

EM/EG

ay/at

red or cream

domino, black and tan, with mask

EG/EG

ay/at

red or cream

domino, black and tan, with mask

EG/E

ay/at

red or cream

domino, black and tan, with mask

EG/e

ay/at

red or cream

red, domino, black and tan, with mask

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Citace:

Dreger, D. L., & Schmutz, S. M. (2010). A new mutation in MC1R explains a coat color phenotype in 2 “old” breeds: Saluki and Afghan hound. Journal of Heredity, 101(5), 644-649.

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Usual turnaround time: 7 business days
1 test price: 38.00 $ without VAT