Testing of dogs: Locus EG

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Locus E^G

The allele E^G is responsible for the grizzle coloration in Saluki breed and domino colour in Afghan Hounds. A mutation in the MC1R-gene occurs (c.233G>T) in both breeds. The phenotype connected with this mutation is light hair on the face and eyebrows.

The mutant E^G-allele is dominant over E and e alleles but recessive to the E^M allele. The expression of E^G allele is influenced particularly by A-locus. The grizzle and domino colours occur only in dogs possessing two a^t alleles. If a dog carries one or two a^y alleles, the grizzle or domino colours will remain hidden. The expression of this colour in puppies within the litter will depend mainly on the fact whether one parent dog has one or two E^Galleles and its partnerthe a^t allele in its genotype. Further, a complicating factor is the presence of E^M that cancels the effect of the E^Gallele.

Locus E hierarchy is as follows: EM> EG> E> EH> e. To determine the final locus E genotype, it is necessary to test all locus E alleles. This test only detects the presence or absence of EG allele.

Rules of inheritance of grizzle and domino coloration:

Grizzle or domino colour can only occur in dogs that have at least one EG allele and two at alleles; an exception is situation when the EG allele is not expressed due its combination with the E^M allele which suppresses the effect of EG allele
If a dog carries at least one EG allele and only one a^t allele, the grizzle or domino colour will not express, but can be passed on to offsprings and expressed in a later generation
If a dog carries at least one EG allele and two ayalleles, the grizzle or domino coloration will not be expressed and will be only passed on to next generations.

1. Possible genotypes - Saluki

Example of Saluki in grizzle color:

saluki grizzle

saluki

Genotype		Colour	Carrier of colour
E^G/E^G	a^t/ a^t	grizzle	eumelanin-and-tan
E^G/E	a^t/ a^t	grizzle	eumelanin-and-tan
E^G/e	a^t/ a^t	grizzle	red, eumelanin-and-tan
E^M/E^G	a^t/ a^t	eumelanin-and-tan, with mask	grizzle, eumelanin-and-tan, with mask
E^M/E^G	a^y/ a^y	red or cream with mask	grizzle
E^G/E^G	a^y/ a^y	red or cream	grizzle
E^G/E	a^y/ a^y	red or cream	grizzle
E^G/e	a^y/ a^y	red or cream	grizzle,red
E^M/E^G	a^y/ a^t	red or cream, with mask	grizzle, eumelanin-and-tan
E^G/E^G	a^y/ a^t	red or cream	grizzle, eumelanin-and-tan
E^G/E	a^y/ a^t	red or cream	grizzle, eumelanin-and-tan
E^G/e	a^y/ a^t	red or cream	red, grizzle, eumelanin-and-tan

2. Possible genotypes – Afghan hound

Example of Afghan hound in domino color:

Afghansky-chrt-domino

Genotype		Colour	Carrier of colour
E^G/E^G	a^t/a^t	domino	black and tan, with mask
E^G/E	a^t/a^t	domino	black and tan, with mask
E^G/e	a^t/a^t	domino	red, black and tan, with mask
E^M/E^G	a^t/a^t	black and tan, with mask	domino, black and tan, with mask
E^M/E^G	a^y/a^y	red or cream	domino
E^G/E^G	a^y/a^y	red or cream	domino
E^G/E	a^y/a^y	red or cream	domino
E^G/e	a^y/a^y	red or cream	domino, red
E^M/E^G	a^y/a^t	red or cream	domino, black and tan, with mask
E^G/E^G	a^y/a^t	red or cream	domino, black and tan, with mask
E^G/E	a^y/a^t	red or cream	domino, black and tan, with mask
E^G/e	a^y/a^t	red or cream	red, domino, black and tan, with mask

Citace:

Dreger, D. L., & Schmutz, S. M. (2010). A new mutation in MC1R explains a coat color phenotype in 2 “old” breeds: Saluki and Afghan hound. Journal of Heredity, 101(5), 644-649.

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