
Testing of dogs: PRA in Spanish Water Dog
Related tests
- Combination Spanish Waterdog NAD + CHG + PRA-prcd + DM* (SOD1A) + EO-PRA + Short Tail + PRA-PDE6B
- Combination Spanish Waterdog 2 NAD + CHG + PRA-prcd + DM* (SOD1A) + EO-PRA + Short Tail + PRA-PDE6B + RSPO2 + CDPA / CDDY (IVDD)
PRA in Spanish Water Dog
The mode of inheritance of the mutation is autosomal recessive.
This means that only individuals who inherit the mutated gene from both
parents will develop the disease. Carriers of the mutated gene are
clinically healthy but pass the mutation on to their offspring. In the
case of a mating between two heterozygous individuals, theoretically 25%
of the offspring will be completely healthy, 50% of the offspring will
be carriers and 25% of the offspring will inherit the mutated gene from
both parents and will therefore be affected by the disease.
The genetic test can clearly reveal the genotype of the animal and is a useful tool for breeders to prevent unintentional breeding of affected puppies.
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References:
Winkler, P.A., Ramsey, H.D., Petersen-Jones, S.M. : A novel mutation in PDE6B in Spanish Water Dogs with early-onset progressive retinal atrophy. Vet Ophthalmol 23:792-796, 2020. Pubmed reference: 32639685.