Testing of dogs: Furnishing - Shedding

EU country
Outside of EU
Czech Republic
Are you VAT registered in EU country other than the Czech Republic?
CZK EUR USD
Usual turnaround time: 7 business days
1 test price: 75.00 $ without VAT

Shedding

The MC5R-gene has been identified as a gene that can impact the degree of shedding in certain dog breeds. The MC5R-gene is expressed in the hair follicle glands that produce the oily, waxy substance called sebum. This secretion of sebaceous glands keeps the hair flexible and assists in lubrication, thermo-regulation and water repellence. The variants of MCR5-gene disrupt the structure of sebum and result in increased shedding. There exist two variants of this gene: A and G. The G-variant is the original gene generated during evolution and is responsible for high degree of shedding. Dogs carrying one copy of this variant have increased shedding and dogs inheriting two copies of this variant have even higher degree of shedding.

.

MC5R

Genotype

Degree of shedding

A/A

Low

A/G

Moderate

G/G

High

The RSPO2-gene is another gene impacting the hair quality. The overall degree of dog shedding can be determined by genetic testing. It is necessary to test the combination of MC5R and RSPO2 genes.

RSPO2

INS/INS - 0 copy of variant responsible for high degree of shedding

WT/INS - 1 copy of variant responsible for high degree of shedding

WT/WT - 2 copies of variant responsible for high degree of shedding

.

MC5R and RSPO2 COMBINATION

Genotype

INS/INS

WT/INS

WT/WT

A/A

A/A, INS/INS → 0

A/A, WT/INS → 1

A/A,WT/WT → 2

A/G

A/G, INS/INS → 1

A/G, WT/INS → 2

A/G, WT/WT → 3

G/G

G/G, INS/INS → 2

G/G, WT/INS → 3

G/G,WT/WT → 4

Degrees of shedding 0,1,2,3,4 – 0 low, 4 high

.

The genetic tests of MC5R-gene and RSPO2-gene reveal the degree of shedding in a dog and can help to select dogs suitable for breeding and thus reduce shedding in puppies. For example, the Labrador breed is suitable for persons suffering from allergy as the degree of shedding is low. A labraddoodle is created by crossing the Labrador retriever and the Puddle. The first generation is not suitable for allergy sufferers as the dogs are shedding a lot, but the second generation (produced by crossing of labradoodles) is more suitable. The genetic testing of MC5R and RSPO2 helps to determine the less shedding individuals. However, even a dog with zero degree of shedding cannot assure that no allergy occurs in any person as the allergy is a complex multifactorial mechanism.

Breed list

This combined test consists of these basic tests

Usual turnaround time: 7 business days
1 test price: 75.00 $ without VAT