
Testing of cats: Feet white (gloving)
Feet white (gloving) in Birma
The white feet of the paws in cats are sometimes called "gloves". This endearing trait in the Birma is caused by mutation c.1035_1036delinsCA in the KIT gene, which plays a role in the regulation and distribution of melanocytes.
The mode of inheritance of the mutation is autosomal recessive. This means that only individuals who inherit the mutated gene from both parents will develop the disease. Carriers of the mutated gene are clinically healthy but pass the mutation on to their offspring. In the case of a mating between two heterozygous individuals, theoretically 25% of the offspring will be completely healthy, 50% of the offspring will be carriers and 25% of the offspring will inherit the mutated gene from both parents and will therefore be affected by the disease.
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References:
Lyons, LA. : Feline genetics: clinical applications and genetic testing. Top Companion Anim Med 25:203-12, 2010. Pubmed reference: 21147473.