Testing of dogs: Curly coat c1

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Curly coat caused by c1 allele

The curly coat caused by c1 allele was originally found in the Portuguese water dog, later it was found that the c1 allele caused curly coat also in many other breeds. The c1 allele in located in the keratin-71 (KRT71) gene, it is a misense mutation c.451C>T. The mutation is inherited autosomal with incomplete dominance. This means that the curly coat will appear in dogs that have inherited the mutated allele from both parents (c1/c1). Heterozygotes (c1/N) will only have wavy coats and dogs not affected by this mutation (N/N) will have straight hair.

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Reference:

Cadieu, E., Neff, M.W., Quignon, P., Walsh, K., Chase, K., Parker, H.G., Vonholdt, B.M., Rhue, A., Boyko, A., Byers, A., Wong, A., Mosher, D.S., Elkahloun, A.G., Spady, T.C., André, C., Lark, K.G., Cargill, M., Bustamante, C.D., Wayne, R.K., Ostrander, E.A. : Coat variation in the domestic dog is governed by variants in three genes. Science 326:150-3, 2009. Pubmed reference: 19713490 . DOI: 10.1126/science.1177808.

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Usual turnaround time: 12 business days
1 test price: 56.00 $ without VAT