Allele e3 in Alaskan and Siberian Husky

The e3 allele is another allele of the E locus that impacts coat colour in dogs. The e3 allele causes white colouring with a very light-yellow tinge in the Alaskan and Siberian husky. The cause is mutation c.816_817del in the MC1R gene. The white colour is carried by individuals with genotype e3/e3 and e1/e3.

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Reference:

Dürig, N., Letko, A., Lepori, V., Hadji Rasouliha, S., Loechel, R., Kehl, A., Hytönen, M.K., Lohi, H., Mauri, N., Dietrich, J., Wiedmer, M., Drögemüller, M., Jagannathan, V., Schmutz, S.M., Leeb, T. : Two MC1R loss-of-function alleles in cream-coloured Australian Cattle Dogs and white Huskies. Anim Genet 49:284-290, 2018. Pubmed reference: 29932470 . DOI: 10.1111/age.12660.