Testing of dogs: Locus D canine (allele d3)

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D Locus (Dilution locus), allele d3

For an overview of dog coat color hierarchy continue to the article Introduction into coat color in dogs.

The MLPH gene (melanophilin gene) is responsible for dilution of the dark pigment eumelanin which turns the original black colour to blue (grey) or the original brown (liver) colour to lilac. There have been identified three different MLPH gene variants so far – each variant is tested separately:

Each variant has a recessive mode of inheritance – the dog must inherit the dilution allele from both parent so that the dilute colour becomes expressed.

There will probably be found other variants responsible for dilute coat colour as there still are breeds with dilute coat colour that is caused by none of the alleles d1, d2 or d3.



Van Buren, S.L., Minor, K.M., Grahn, R.A., Mickelson, J.R., Grahn, J.C., Malvick, J., Colangelo, J.R., Mueller, E., Kuehnlein, P., Kehl, A. : A Third MLPH Variant Causing Coat Color Dilution in Dogs. Genes (Basel) 11:, 2020. Pubmed reference: 32531980.

Bauer, A., Kehl, A., Jagannathan, V., Leeb, T. : A novel MLPH variant in dogs with coat colour dilution. Anim Genet 49:94-97, 2018. Pubmed reference: 29349785.

Drögemüller, C., Philipp, U., Haase, B., Günzel-Apel, A.R., Leeb, T. : A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs. J Hered 98:468-73, 2007. Pubmed reference: 17519392.

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Usual turnaround time: 12 business days
1 test price: 49.00 $ without VAT