Testing of dogs: Locus D canine (allele d1)

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Usual turnaround time: 4 business days
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D Locus (Dilution locus), allele d1

For an overview of dog coat color hierarchy continue to the article Introduction into coat color in dogs.

This mutation responsible for lighter colours has been identified on the canine chromosome 25 in the MLPH-gene (melanophilin gene) (Drögemüller et al. 2007). The mutation is c.-22G>A in MLPH gene. The allele with this mutation is designated as d1-allele.

The inheritance of the diluted colour is autosomal recessive that means that the phenotype of diluted colour is expressed in case of genotype d1/d1. In dogs with black coat, the black turns into grey (blue) and the red colour turns into cream colour.

MLPH gene mutation is responsible for coat color dilution especially in breeds:

  • Labrador Retriever
  • Labradoodle
  • German Pinscher
  • Doberman
  • Rhodesian Ridgeback
  • Australian Shepherd
  • Briard
  • Great Dane
  • Large Munsterlander
  • Newfoundland

Other variant of MPLH-gene responsible for colour dilution has been discovered in many dog breeds such as Chow-Chow, Sloughi, Beagle, French bulldog, Papillon, Staffordshire Bull Terrier and Thai Ridgeback and other breeds – you can read more about the d2-variant here: c.705G>C of MLPH-gene (d2-allele).

Dogs with diluted colour can be compound heterozygotes d1/d2 -> continue here to order a double-test for D-locus (d1 + d2 alleles).

There will be probably discovered other gene variants responsible for colour dilution as there are still breeds with colour dilution that is caused neither by d1 nor d2 allele.

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Usual turnaround time: 4 business days
1 test price: 38.00 $ without VAT