Testing of dogs: Locus D canine (allele d2)

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D Locus (Dilution locus), allele d2

For an overview of dog coat color hierarchy continue to the article Introduction into coat color in dogs.

The MLPH-gene that corresponds to D-locus is responsible for the so-called dilute coat colour in dogs. The recessive alleles in this region are marked with letter d. The presence of a variant in MLPG-gene affects the transport of melanosomes in melanocytes and results in dilution of coat colour.

With the exception of the variant c.22G>A in MLPH-gene (d1-allele) that was described in different breeds a long time ago ( e.g. Labrador Retriever, Labradoodle, German pinscher, Dobermann,  Rhodesian Ridgeback, Australian shepherd, Briard, German doga, Large Munsterlander Whippet or Newfounland dog), a new mutation causing dilution of coat colour in many other breeds such as Chow-Chow, Sloughi, Beagle, French bulldog, Papillon, Staffordshire Bull Terrier and Thai Ridgeback , has been discovered in  2018. It is the variant c.705G>C of MLPH-gene (d2-allele).

The inheritance of diluted colour is autosomal recessive that means that this trait must be inherited from each of the dog´s parent to express dilute coat colour.  In dogs with black coat, the colour is diluted to grey (blue), in brown dogs to lilac.

The dog genotype with diluted coat colour can be either heterozygous, i.e. compound heterozygote d1/d2 (each gene variant was inherited from each of dog´s parents) or homozygous d2/d2 or d1/d1. The variant c.705G>C of MLPH-gene or the presence of d2-allele is the second possible variant explaining the dilution of coat colour in dogs. Non-diluted dogs have at least one dominant not diluted D-allele.

There will be probably discovered other gene variants responsible for colour dilution as there are still breeds with colour dilution that is caused neither by d1 nor d2 allele.

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Usual turnaround time: 7 business days
1 test price: 38.00 $ without VAT