Testing of dogs: Locus EH

Usual turnaround time: 12 business days

1 test price: 49.00 $ without VAT

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Locus E^H

Locus E^H is responsible for the specific coloration – sable in American and English Cocker Spaniel. Dogs possessing this allele have partially inhibited expression of eumelanin pigment. The coat colour is paler and it can be observed the gradual transition of colours from golden to brown with brown colour covering dog´s head top and back. In all dogs with a sable phenotype, a mutation c.250G>A in its transmembrane domain has been found when sequencing the MR1 gene.

Example of Cocker Spaniel in sable color:

Kokršpaněl EH

Locus E hierarchy is as follows: EM> EG> E> EH> e. To determine the final locus E genotype, it is necessary to test all locus E alleles. This test only detects the presence or absence of EH allele.

E^H allele is dominant over the e allele but is recessive contrary to E and E^Malleles. The resulting genotypes may be:

Genotype	Color
E^H/ E^H	sable colored; carrier of sable
E^H/e	sable colored; carrier of sable
E/E^H	carrier of sable
E^M/E^H	carrier of sable

Genotypes of parent dogs	Theoretical representation of offspring genotypes in the litter
E^H/ E^H+ E^H/ E^H	100 % E^H/ E^H
E^H/ E^H+ E^H/e	50 % E^H/ E^H; 50 % E^H/e
E^H/ E^H+ E^H/E	50 % E^H/ E^H; 50 % E/E^H
E^H/ E^H+ E^M/E^H	50 % E^H/ E^H; 50 % E^M/E^H
E^H/e + E/E^H	25 % E^H/ E^H; 25 % E^H/e; 25 % E/E^H; 25 % E/e
E^H/e + E^M/E^H	25 % E^H/ E^H; 25 % E^H/e; 25 % E^M/e; 25% E^M/E^H
E/E^H + E/E^H	25 % E^H/ E^H; 50 % E/E^H; 25 % E/E
E/E^H + E^M/E^H	25 % E^H/ E^H; 25 % E/E^H; 25 % E^M/E; 25% E^M/E^H
E^M/E^H +E^M/E^H	25 % E^H/ E^H; 50 % E^M/E^H; 25 % E^M/E^M
E^H/e + E^H/e	25 % E^H/ E^H; 50 % E^H/e; 25 % e/e

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