Testing of cats: Mucopolysaccharidosis VI

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Usual turnaround time: 12 business days
1 test price: 56.00 $ without VAT

Related tests

  • Combination House Cat and European Cat 2 Mucopolysaccharidosis I + Mucopolysaccharidosis VI + Mucopolysaccharidosis VII + Niemann-Pick disease, type C1 + Congenital Myotonia + Hyperlipoproteinaemia + Dihydropyrimidinase deficiency
  • Combination Siamese cat GM1 + Mucopolysaccharidosis VI + Mucopolysaccharidosis VI + Cystinuria, type B + Factor XII deficiency + Glaucoma 3 + PRA-rdAc + MDR1 + Blood Group DNA test

Mucopolysaccharidosis VI

The mode of inheritance of the mutation is autosomal recessive. This means that only individuals who inherit the mutated gene from both parents will develop the disease. Carriers of the mutated gene are clinically healthy but pass the mutation on to their offspring. In the case of a mating between two heterozygous individuals, theoretically 25% of the offspring will be completely healthy, 50% of the offspring will be carriers and 25% of the offspring will inherit the mutated gene from both parents and will therefore be affected by the disease.

The genetic test can clearly reveal the genotype of the animal and is a useful tool for breeders to prevent unintentional breeding of affected kittens.

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References:

Yogalingam, G., Litjens, T., Bielicki, J., Crawley, A.C., Muller, V., Anson, D.S., Hopwood, J.J. : Feline mucopolysaccharidosis type VI - characterization of recombinant n-acetylgalactosamine 4-sulfatase and identification of a mutation causing the disease Journal of Biological Chemistry 271:27259-27265, 1996. Pubmed reference: 8910299.

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Usual turnaround time: 12 business days
1 test price: 56.00 $ without VAT