
Testing of dogs: PRA-prcd
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PRA-prcd (progressive rod-cone degeneration)
The progressive rod-cone degeneration (PRA-prcd) is caused by mutation c.5G>A in PRCD gene (former designated as 1298G>A). The PRCD gene affects mainly retina with the same expression level in retinal pigment epithelium, photoreceptor cells and in the ganglion cells. The mutation causes exchange of nucleon TGC basis for TAC basis that results in binding of other amino acid and structural and functional changes in the resulting protein.
This genetic disorder causes that photosensitive cells of the retina (rods and cones) gradually deteriorate and die. The onset of the disease is in adolescence or in early adulthood. However, the age of the disease onset and the disease intensity depends on the specific breed. The rod-type cells lose their function first and the affected dogs will develop night blindness. Over time the disease continues with cone degeneration and progresses to complete blindness.
The genetic testing can help to clarify the diagnosis. It can determine the dog genotype and is the solution for gradual elimination of prcd occurrence in a breed. It is necessary to be aware that not all retinal diseases belong in progressive retina atrophy group of disorders and not all are a variant of PRA-prcd. In many breeds, the cause of PRA inheritance has not been still clarified. It is also possible that several mutations can be responsible for retinal atrophy in one breed. Therefore, we recommend that an eye examination by a veterinary ophthalmologist is performed every year.
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The analysis is performed by partner laboratory.
Result report preview
Breed list - total 64 different breeds. Show list of all breeds Hide breeds
- American Cocker Spaniel
- American Hairless Terrier
- Australian Cattle Dog
- Australian Labradoodle
- Australian Shepherd
- Australian Silky Terrier
- Australian Stumpy Tail Cattle Dog
- Barbet - French Water Dog
- Bearded Collie
- Bolognese
- Chesapeake Bay Retriever
- Chihuahua
- Chinese Crested Dog
- Cockapoo
- Coton de Tulear
- Curly Coated Retriever
- English Cocker Spaniel
- Entlebucher Mountain Dog
- Field Spaniel
- Finnish Lapphund (Suomenlapinkoira)
- German Spitz
- German Spitz - Giant Spitz
- Golden Retriever
- Goldendoodle
- Jack Russell Terrier
- Jämthund
- Japanese Chin
- Karelian Bear Dog
- Kuvasz
- Labrador Retriever
- Lancashire Heeler
- Lapponian Herder (Lapinporokoira)
- Manchester Terrier
- Miniature American Shepherd
- Norrbottenspets (Norrbottenspitz)
- Norwegian Elkhound Black (Norsk Elghund Sort)
- Norwegian Elkhound Grey (Norsk Elghund Grĺ)
- Nova Scotia Duck Tolling Retriever
- Papillon
- Poodle Medium
- Poodle Miniature
- Poodle Multicolored
- Poodle Standard
- Poodle Toy
- Portuguese Warren Hound - portuguese Podengo
- Portuguese Water Dog
- Puli
- Pyrenean Sheepdog - smooth faced
- Pyrenean Sheepdog Long-haired
- Romagna Water Dog (Lagotto romagnolo)
- Russian Black Terrier
- Russian-European Laika
- Russkaya Tsvetnaya Bolonka
- Schipperke
- Serbian Hound
- Spanish Waterdog
- Swedish Lapphund
- Tibetan Terrier
- Toy Australian Shepherd
- Toy Spitz (Pomeranian)
- Xoloitzcuintle Intermediate
- Xoloitzcuintle Standard
- Xoloitzuintle Miniature
- Yorkshire Terrier