Testing of dogs: PRA-prcd

Usual turnaround time: 7 business days

1 test price: 56.00 $ without VAT

CZK / EUR / USD

Related tests

6-test for Australian Labradoodle ALAEU members can apply 10% discount
CDPA / CDDY (IVDD) + PRA-prcd for Nova Scotia Duck Tolling Retriever, Coton de Tulear, American Cocker Spaniel and more
CEA + HC + PRA test combination CEA + HC + PRA for Shepherds
CEA + PRA-prcd test combination for dogs
CNM + PRA doubletest for Labrador Retrievers for better price
CNM + PRA + OSD + EIC* test combination for Labrador Retrievers
Chondrodysplasia + PRA-prcd combinations of tests for Karel Bear Dogs
FN + PRA FN + PRA for English Cocker Spaniels
FN + PRA + AMS
GR-PRA1 + GR-PRA2 + PRA-prcd
GSDII + PRA-Prcd + DM (SOD1A)
HC + PRA test combination HC + PRA for Shepherds
Ichthyosis + GR-PRA1,2 + PRA-prcd + GRMD test package for gold retrievers
Ichthyosis + PRA-prcd + GRMD Combi-test for Golden Retrievers
MDR1 + HC + PRA test combination for Shepherds
MDR1 + HC + PRA-prcd + DM + CEA test combination for Shepherds
MDR1 + PRA test combination for Shepherds
PLL + PRA for Chinese Crested dogs, Australian cattle dogs and some other breeds with PLL and Prcd assumption
PLL + PRA + PRA-rcd3 for Chinese Crested dogs
PLL + PRA-prcd + PRA-rcd4 for Australian Cattle Dogs and Tibetan Terriers
PLL + Prcd + DM (SOD1A)
PLL + Prcd + DM (SOD1A) + vWDI
PLL + Prcd + DM (SOD1A) + vWDI + hairlessness
PRA-prcd + DNA profile combination of PRA-prcd and DNA profile
PRA-prcd + PRA-rcd3
PRA-prcd + PRA-rcd4 Double test for lower price!
PRA-prcd + RSPO2 + GM1 combination of tests for Portuguese water dogs
cord1-PRA + PRA-prcd
vWD I + PRA-prcd for Poodles, Labradoodles, Goldendoodles

PRA-prcd (progressive rod-cone degeneration)

The progressive rod-cone degeneration (PRA-prcd) is caused by mutation c.5G>A in PRCD gene (former designated as 1298G>A). The PRCD gene affects mainly retina with the same expression level in retinal pigment epithelium, photoreceptor cells and in the ganglion cells. The mutation causes exchange of nucleon TGC basis for TAC basis that results in binding of other amino acid and structural and functional changes in the resulting protein.

This genetic disorder causes that photosensitive cells of the retina (rods and cones) gradually deteriorate and die. The onset of the disease is in adolescence or in early adulthood. However, the age of the disease onset and the disease intensity depends on the specific breed. The rod-type cells lose their function first and the affected dogs will develop night blindness. Over time the disease continues with cone degeneration and progresses to complete blindness.

The genetic testing can help to clarify the diagnosis. It can determine the dog genotype and is the solution for gradual elimination of prcd occurrence in a breed. It is necessary to be aware that not all retinal diseases belong in progressive retina atrophy group of disorders and not all are a variant of PRA-prcd. In many breeds, the cause of PRA inheritance has not been still clarified. It is also possible that several mutations can be responsible for retinal atrophy in one breed. Therefore, we recommend that an eye examination by a veterinary ophthalmologist is performed every year.

The analysis is performed by partner laboratory.

Result report preview

Breed list - total 64 different breeds. Show list of all breeds Hide breeds